Notably, these data include all deaths in the United States that occurred throughout the pandemic, from February 2020 to July 1, 2022, including deaths among unvaccinated individuals. Based on data from the National Vital Statistics System (NVSS) at NCHS ( Risk for COVID-19 Infection, Hospitalization, and Death By Age Group), compared with ages 18–29 years, the risk of death is 25 times higher in those ages 50–64 years, 60 times higher in those ages 65–74 years, 140 times higher in those ages 75–84 years, and 340 times higher in those ages 85+ years. To learn more about the process of CDC’s systematic reviews, see CDC systematic review process.Īge remains the strongest risk factor for severe COVID-19 outcomes, with risk of severe outcomes increasing markedly with increasing age. Since May 2021, the process has been updated to include a CDC-led review process that uses rigorous systematic review methods. As the literature grew, CDC investigators categorized the literature by study design. For instance, preliminary versions of this list focused on providing the latest information based on descriptive data. The methods used to assess the conditions have changed during the pandemic as the amount of literature and types of studies increased.
The information reflects evidence regarding underlying medical conditions and is intended to help healthcare professionals make informed decisions about patient care and to increase the awareness of risk among their patients. Evidence used to inform the list of underlying conditions was determined by CDC reviewers based on available literature about COVID-19 at time of review. This page summarizes data from published reports, scientific articles in press, unreviewed pre-prints, and internal data that were included in literature reviews conducted by subject matter experts.
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